A few niggling difficulties were apparent.
At the time, the chemical hypothesis, based on analogy with Ephraim Racker's mechanism of substrate level phosphorylation linked to triose phosphate oxidation, seemed secure. It is interesting to look back and remember how sparse the clues were on which the hypothesis was based. In retrospect, it was a great strength of this first paper that Peter did not go into too much detail the ideas were new and strange, and were introduced to a field dominated by a few major laboratories with their own different ideas about how the coupling between electron transport and phosphorylation occurred. Mitchell's 1961 paper outlined the hypothesis in the form of several postulates which could be subjected to test. Ogston, on the coupling of electron transport and ATP synthesis to proton gradients.
Lundergard, Robert Robertson, and Robert Davies and A.G. The seeds of the chemiosmotic hypothesis, which lay in Peter's attempts to understand bacterial transport and homeostasis, were pollinated by the earlier ideas of H. The Nobel Prize for Chemistry in 1978, awarded to Peter Mitchell as the sole recipient, recognized his predominant contribution towards establishing the validity of the chemiosmotic hypothesis, and ipso facto, the long struggle to convince an initially hostile establishment. Peter Mitchell's 1961 paper introducing the chemiosmotic hypothesis started a revolution which has echoed beyond bioenergetics to all biology, and shaped our understanding of the fundamental mechanisms of biological energy conservation, ion and metabolite transport, bacterial motility, organelle structure and biosynthesis, membrane structure and function, homeostasis, the evolution of the eukaryote cell, and indeed every aspect of life in which these processes play a role.
Peter Mitchhell and the chemiosmotic hypothesis
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